Custom Synthesis Services

Custom synthesis with tritium

Custom synthesis with carbon-14

Custom synthesis of non-labeled compounds

Custom synthesis with sulphur-35

Custom synthesis with carbon-13

Oligonucleotide custom synthesis with tritium, carbon-14 or sulphur-35

Guaranteed Custom Synthesis with Tritium

Custom Synthesis Quotation Form

The tritium custom synthesis offered by MB is designed to minimize uncertainty about the outcome of a project. A detailed quotation is used to outline the specifications of the final product before work is started. The compound will meet the agreed upon specifications for minimum specific activity, total activity, and purity (usually 97% by HPLC) or no fee is charged.

A variety of labeling techniques and synthetic procedures are used to efficiently tritiate even relatively unstable biochemicals.

Tritium custom synthesis includes the following:

• Performance of the labeling procedure and / or synthesis
• Purification by paper, thin layer, or high performance liquid chromatography
• Determination of the final product's purity, specific activity, and total activity
• Documentation of the final product's purity, specific activity, and total activity in a product data sheet

Custom Synthesis with Carbon-14

Custom Synthesis Quotation Form

MB has a long standing record of accomplishments in the multiple step preparation of carbon-14 organic molecules. Over the past 35 years our staff has aquired considerable expertise in radiosynthesis of carbon-14 labeled biochemicals, pharmaceuticals, agrochemicals, polymers, dyes, and organic reagents.

Carbon-14 custom synthesis includes the following:

• Performance of the synthesis as outlined in our quotation
• Purification by paper, thin layer, or high performance liquid chromatography
• Determination of the final product's purity, specific activity, and total activity
• Documentation of the final product's purity, specific activity, and total activity in a Product Data Sheet

Custom Synthesis of Non-labeled Compounds

Custom Synthesis Quotation Form

Our synthetic team has acquired extensive experience in the multi-step preparation of nucleosides, nucleotides and a variety of other complex organic molecules.  Over the past 35 years our staff has successfully prepared hundreds of biochemicals, pharmaceuticals, agrochemicals, polymers, dyes and organic reagents.

Custom Synthesis with Sulphur-35

Custom Synthesis Quotation Form

A variety of techniques are used including a sulphur-35 labeling method developed by MB scientists to efficiently label Thiopurines and Thiopyrimidines up to nucleotide level.

Sulphur-35 [³⁵S] custom synthesis includes the following:

• Performance of the synthesis as outlined in our quotation
• Purification by paper, thin layer or high performance liquid chromatography
• Determination of the final product's purity, specific activity and total activity
• Documentation of the final product's identity, purity, specific activity and total activity

Custom Synthesis with Carbon-13

Custom Synthesis Quotation Form

Extensive experience in preparation of nucleic acid components and their analogs makes our efficient custom carbon-13 synthesis the right choice.

Carbon-13 custom synthesis includes:

• Performance of the synthesis as outlined in our quotation
• Purification by paper, thin layer or high performance liquid chromatography
• Determination of the final product's chemical purity
• Documentation of the final product's identity, chemical purity and isotopic enrichment

Oligonucleotide Custom Synthesis with Tritium, Carbon-14 or Sulphur-35

Custom Synthesis Quotation Form

• Labeling of phosphodiester phosphorothioate oligonucleotides with phosphoramidites of DMT-Td, [4,6-¹⁴C]- or DMT-Td, [methyl-³H]- incorporated in specific position during synthesis
• High molar specific radioactivity (100µCi for each µmol of Td, [4,6-¹⁴C]- incorporated or up to 3mCi for each µmol of Td, [methyl-³H]- incorporated)
• Multiple position labeling and multiple isotope labeling available
• Radiosulfur labeling in specific position (single or multiple) of phosphorothioate oligonucleotides, to incorporate up to 500 µCi of ³⁵S for each µmol of nucleotide labeled
• Purification by HPLC

Last Updated on Saturday, April 05, 2008 11:36:37 AM
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