Oligonucleotide Custom Synthesis with Carbon 14 or Tritium

Moravek is licensed by the California Department of Public Health, Food and Drug Branch, for the preparation, and 14C or 3H labeling of active pharmaceutical ingredients (API) for research. In addition, Moravek is allowed to handle schedule I-V classified compounds under DEA authority.

Moravek is able to perform the custom syntheses of your 14C or 3H oligonucleotide which includes, but is not limited to:

  • Labeling of phosphodiester phosphorothioate oligonucleotides with phosphoramidites of DMT-Td, [4,6-14C]- or DMT-Td, [methyl-3H]- incorporated in specific position during synthesis
  • High molar specific radioactivity (100μCi for each μmol of Td, [4,6-14C]- incorporated or up to 3mCi for each μmol of Td, [methyl-3H]- incorporated)
  • Multiple position labeling and multiple isotope labeling available
  • Purification by HPLC