Radiolabeling has undeniably revolutionized drug discovery and development processes, allowing researchers to take a deeper look at drugs during human trials. Tritium is one isotope scientists use in this process and has proved to be invaluable. Read this brief look at the role of tritium in radiolabeling and what has made its application so beneficial.
(more…)When some people hear the terms “drug substances” and “drug products,” they might think these are one and the same. However, the meanings of these phrases are quite different. Knowing these distinctions can help you successfully achieve your goals in the pharmaceutical industry. Read on to learn about the difference between drug substances and drug products.
(more…)A compound’s purity is critical for pharmaceutical companies since it can directly affect a drug’s therapeutic efficacy and safety profile. This makes compound purification more than a procedural step in drug research and development. Read on to understand compound purification practices and how they work.
What Is Compound Purification?
Before we review the various practices, it’s important to understand how compound purification works. It is the process of removing a substance from a chemical compound. The goal is to isolate and remove impurities, leaving behind a product of the highest possible purity.
What Are the Various Purification Methods?
Now that you know how this procedure works, you can gain an understanding of compound purification practices. The diversity of chemical compounds necessitates a range of purification techniques for different impurities and physical states of the target compound. Let’s take a closer look at several of the methods.
Filtration
Filtration is especially useful in separating solid impurities from liquid samples. With the help of a porous barrier, scientists can separate solid particulate matter from the liquid.
Sublimation
Another technique is sublimation, which scientists use to purify compounds that transition directly from a solid to a gas when heated, bypassing the liquid phase. This method is particularly effective for separating volatile compounds from non-volatile or less volatile impurities.
Crystallization
Crystallization involves dissolving a solvent at high temperatures and cooling the solution. After the pure compound becomes a solid, you can separate it from the impure portions.
Distillation
When scientists perform distillation, they separate portions of a liquid at various boiling points. They will heat the mixture to vaporize the most non-volatile component. Then, they condense it into a liquid form in a separate container.
Chromatography
Chromatography involves separating components of a mixture with porous mediums. After the ingredients undergo this separation, scientists can obtain the pure components they need. This method is incredibly precise and indispensable in the analysis and purification of complex mixtures.
As we’ve seen, compound purification is a critical aspect of pharmaceutical research and laboratory work. Moravek can help you in this process with high and ultra-high-performance liquid chromatography that determines the radiochemical purity of your substance. We have experience in assisting clients as they advance their scientific discoveries and ensure the safety and effectiveness of their pharmaceutical products.
A patient undergoing treatment for their medical condition can feel at ease knowing the treatment passed a clinical trial to ensure its effectiveness and safety. Read below to learn what goes into clinical trials and studies to ensure your tests will be thorough.
(more…)Patients taking prescriptions expect their medications to be safe for consumption and provide them with an effective dosage that will allow them to get better. However, chemical compound degradation can get in the way of these goals and have a devastating impact on your business. Read on to learn about the dangers of chemical compound degradation and how you can ensure the highest standards of drug safety and effectiveness.
(more…)When you need custom chemical synthesis services, you want to ensure you hire a qualified contractor. After all, your choice can strongly impact the quality and outcome of your project. Here are five things to look for in a custom chemical synthesis company to ensure the success of your work.
(more…)Oligonucleotides stand at the forefront of a healthcare revolution in the quest to tailor medical treatments to individual genetic profiles. These powerful molecular tools are carving out a significant medical niche and presenting groundbreaking opportunities. Read on to learn about the importance of oligonucleotides in medicine and how they are reshaping the way we approach complex diseases.
(more…)Researchers and scientists can utilize a broad range of tools and substances, including stable-labeled compounds, to assist them in their work. They can harness the unique properties of these compounds to peel back the layers of molecular mysteries and gain unique insights. If you want to learn more about using this analytical method in your research, read this overview of stable-labeled compounds and their applications.
(more…)Artificial intelligence (AI) is rapidly transforming the pharmaceutical industry, introducing groundbreaking developments and remarkable efficiencies. This technology is reshaping how companies discover and manufacture drugs. Read on to learn about several innovative uses of AI in the pharmaceutical sector.
(more…)It is critical for pharmaceutical firms to find ways to stay efficient and competitive. A strategy that can help is hiring a third party for chemical manufacturing. If you are on the fence about employing such a method, here are four reasons to consider outsourcing chemical manufacturing. You can unlock many advantages and position yourself for success in today's dynamic market.
(more…)When your employees use chemicals in your laboratory, you need to ensure they use the right substances for the right processes. But that’s where the process of chemical labeling can be helpful for your business. Read on to learn about what chemical labeling is and why it’s important for both your lab and the safety of your associates as they conduct their research.
(more…)Custom organic synthesis represents a new frontier in the scientific world, shaping the landscape of drug discovery and development. From the synthesis of intricate molecular structures to the generation of novel compounds with unique properties, custom organic synthesis promises to be exciting, transformative, and deeply influential. Get a brief look at the future of this process.
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