Understanding Inactive Substances in Pharmaceuticals
People usually focus on active substances inside the product that will improve their health when they think about pharmaceuticals. They don’t always consider the importance of the other ingredients inside. But those substances also play a vital role. Continue reading to learn more about inactive substances in pharmaceuticals and the important roles they play in your products.
What Are Inactive Substances?
Inactive substances, commonly known as excipients, are components of a pharmaceutical product that do not impact your health. However, these substances can carry the active drugs within the body and enhance their overall effectiveness. This feature makes the selection of inactive substances important so that they do not interact negatively with the active substances and compromise the drug’s safety and efficacy.
How Can Inactive Substances Enhance Pharmaceuticals?
Inactive substances play numerous essential roles in pharmaceuticals. For example, an excipient can extend the shelf life of your product so that it doesn’t expire quickly. They can also enhance the absorption rate of a drug by altering the dissolution rate of an active pharmaceutical ingredient (API) or promoting its absorption through biological barriers.
They can even add to the flavor of a medicine or add to its appearance, making it more appealing to the consumer. You have many options as a manufacturer, regarding inactive ingredients.
How Can I Ensure My Ingredients Are Safe?
Now that you have a better understanding of inactive substances in pharmaceuticals, it is important to know how to guarantee the safety of these ingredients. Although you will ultimately seek approval from the U.S. Food and Drug Administration (USDA), you can also review its Inactive Ingredient Database (IID) when beginning the development phase.
The IID lists inactive ingredients that manufacturers included in previously approved drugs. It is also wise to review the standards set by the U.S. Pharmacopeia, which focuses on ensuring pharmaceutical products are effective and safe for those who must take them.
Companies can provide higher-quality medications to healthcare providers and patients by understanding the critical roles inactive substances play in pharmaceuticals. Moravek offers custom API manufacturing services for products in phase 0 and 1 clinical trials. We focus on making our system GMP-compliant so we can meet your needs and regulatory requirements.