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Radiolabeling At Work: Treating Kidneys With Nanotechnology
Acute kidney injury (AKI), previously known as acute renal failure, kills around 1.7 million people every year. The kidneys produce a rapid buildup of nitrogenous wastes and also decrease urine output; severe complications -- including muscle weakness, paralysis, and heart rhythm problems -- ensue.
Good Manufacturing Practices As Stated By The RDRC And FDA
The U.S. has long been a driver of scientific discovery. From cures to vaccines, medical implementation of these advances has been at the forefront of our nation's goals. The finding of radiolabeling applications is one such breakthrough. Radiolabeling (and isotopic labeling) is valuable to the developments of other breakthroughs: C14 radiolabeling (also known as 14C labeling)...
Clinical Trials: Taking A Look At The Phases Involved
Getting a new drug off the ground takes a lot of work. You have to follow stringent (and very specific) FDA guidelines, exercise top-tier clean room standards (and GMP standards) to prevent contamination and reduce risk, and perform dozens of radiolabeled tests to ensure the drug is going to the right target within the human...
Storing Pharmaceuticals: Important Guidelines to Consider
When it comes to pharmaceuticals, proper storage is absolutely essential. Guidelines and regulations for GMP storage conditions are in place because even if a product is manufactured properly, something can go wrong if the product is stored improperly. So let's explore a few basic guidelines to keep in mind when storing pharmaceuticals.
Why are GMP Regulations Important in Today's Pharmaceutical Labs?
With the U.S. holding more than 45% of the global pharmaceutical market, it's important for laboratories to abide by certain regulations. The regulations in place help to maintain pharmaceutical quality so they're safe for consumers. Good Manufacturing Practice (GMP) regulations give pharmaceutical labs standards they need to meet to ensure their products are both...
C14 Radiolabeling: What You Need to Know
Carbon is an element that has been used for a variety of scientific purposes over the years, like radiocarbon dating, which was developed around 1946 by Willard F. Libby. But in today's pharmaceutical labs, carbon 14 plays a crucial role in drug development. And because of depleting supplies and increasing prices, carbon 14 production is...
What Exactly Is Radiolabeling?
Radiolabeling is a process that is frequently used in medicine, drug research and development, and environmental case studies. Using this process, researchers can track the movement or breakdown of target molecules. For instance, drug researchers can see how a new drug is metabolized as it travels through the test subject's body. To accomplish this,...
What Kind of Fume Hoods Are Available to Today's Labs?
While there are a lot of essential pieces of equipment used in laboratories, fume hoods are one of the most important devices labs have. When lab technicians are working with materials that are classified with health hazards, it's important to work in an area that has a fume hood so the harmful fumes can be...
3 Benefits Cleanrooms Can Offer
With the United States being the number one largest national producer of chemical products in the world, it's no surprise that there is an astounding number of laboratories throughout the country. And whether that laboratory is engaged in Carbon 14 production or pharmaceutical research and development, many laboratory settings contain cleanrooms. In labs, cleanrooms...
Why is Temperature Monitoring Important in Labs?
When it comes to handling sensitive items in laboratories, like radiolabeled compounds, it's important to make sure they're stored, worked with, and manufacturers in proper temperatures. Under proper GMP storage conditions, like in a cleanroom, compounds and chemicals can be manufactured and used correctly. Cleanrooms are an important part of any laboratory -- compared to...
How Do Chemical Manufacturers Assess Purity?
Testing the purity of substances is one of the most important tasks chemical manufacturers are faced with. If an impure substance is used, it could cause adverse effects. For example, a 2012 fungal meningitis outbreak that caused the deaths of 48 people was traced back to a pharmacy that hadn't been using proper cleaning and...
The Importance of Fume Hoods in Laboratory Settings
Today's technology makes laboratory settings safer and more effective than ever. From clean rooms to effectively removing fumes, scientists can do it all with technology. In fact, electronic sensing devices allow scientists to maintain and monitor the humidity in clean rooms as close as plus or minus 1%. But despite advances in technology, when it...