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Methods for Labeling Nucleic Acids
Modifying nucleic acids with tags allows for the detection and purification of the nucleic acid (DNA or RNA) during synthesis. The resulting nucleic acid probes identify or recover other interacting molecules as well. Radiolabeled compound suppliers use enzyme and chemical methods to label the nucleic acid at the 5’ or 3’ ends of the oligonucleotide, as well...
What You Should Know About Drug Absorption
For a drug to be clinically effective, it must absorb into the bloodstream. Absorption is the process of a drug moving from the site of delivery to the bloodstream. The absorption process is crucial to treatment, but it is complex and can be challenging to understand. Here’s what you should know about drug absorption.
What It Means To Be a GMP Certified Manufacturer
Quality control is one of the most critical aspects of manufacturing and selling products. That's why it's crucial to use a GMP certified manufacturing company to manufacture goods, especially pharmaceuticals. But what does it mean to be a GMP certified manufacturer? Let's take a look. What Is GMP GMP stands for good manufacturing practice, and it...
The Differences Between GMP and cGMP
GMP stands for good manufacturing practice, a process that is highly important in any manufacturing facility. The Food and Drug Administration's GMP guidelines ensure the safety and quality of all products. Just like GMP, cGMP is also highly sought after in the manufacturing industry. Let's take a more in-depth look at the differences between GMP...
The Value of Growing for Regulatory
Every new product that hits the market, including new pharmaceuticals, must follow regulatory compliance. Regulatory authorities issue guidelines and rules for development, licensing, manufacturing, marketing, labeling, and more. While strict guidelines may seem like a pain, they are highly crucial to pharmaceuticals' safety and efficacy and their development process. Improved standard methods, efficiency, and costs...
Understanding DNA and RNA Radiolabeling
There is a lot of information that goes into understanding DNA and RNA radiolabeling. Radioisotope labeling is a traditional method for nucleic acid labeling, and it is highly essential to the detection, visualization, and purification of DNA and RNA.
Different Types of Impurities in Pharmaceuticals
An impurity in pharmaceuticals is classified as any component that is not the entity defined as the drug substance. In addition, for a drug product, any component that is not a formulation ingredient is considered an impurity. There are three different types of impurities in pharmaceuticals that API manufacturing companies must be wary of. Below, we provide a...
How Drugs Are Metabolized in the Body
Metabolism is the biotransformation that some drugs undergo when the body chemically alters them. Metabolism is an important process that produces the intended therapeutic effects of a certain drug and eliminates the drug from the body through urine or bile. Drug metabolism can be tricky to understand—here’s everything you need to know about how drugs...
The Importance of GMP in Pharmaceutical Manufacturing
Good manufacturing practice or GMP is a system that ensures products are consistently produced and controlled according to quality standards. The importance of GMP in pharmaceutical manufacturing is to minimize the risks involved in any pharmaceutical process, such as custom radiolabeling, that can put consumers at risk if the proper quality control isn’t in place.
Understanding Active Pharmaceutical Ingredients
Have you ever wondered how pharmaceutical drugs work? The ingredients in a pharmaceutical drug are responsible for the physiological reaction your body has to the medication. Many components are involved in the development of pharmaceuticals, but active pharmaceutical ingredients are the ingredients that produce the intended effects of the drug an individual is taking.
How To Choose the Right CMO for Your Pharmaceutical Product
The development of a new drug is a complex task and requires many evaluations and decisions before a commercial launch. Some biotech and small pharmaceutical companies are choosing to outsource most or all their drug manufacturing efforts throughout the development phase with a contract manufacturing organization. Choosing the right contract manufacturer is imperative in pharmaceutical...
How Radiosynthesis Supports Drug Development
The demand for radioisotopes in medicine is growing at a rapid rate, as radioactive compounds can be used as tracers to understand mass balance and metabolic profiles of drugs. Carbon-14 is a common radioactive isotope that’s used as a tracer in biochemistry methods such as DMPK and ADME studies.